Lizzo was just called a 'weight loss drug' on South Park. Now, she's responded.

You don't have to watch South Park to know the show enjoys ruthlessly roasting celebrities — and it isn't afraid of pushing boundaries.

The latest target? Controversial singer Lizzo.

In a recent special titled South Park: The End Of Obesity, the show provides some spicy commentary on the rise of weight-loss drugs like Ozempic and Mounjaro, while also taking specific aim at Lizzo's personal brand of body positivity.

And, yes — she posted her real-time reaction watching it.

Watch: Lizzo's 'Watch Out For The Big Grrrls' — Official Trailer. Post continues below.

Mirroring the episode in a recent Instagram clip, the About Damn Time artist shared a "blind react" with her viewers.

"Guys, my worst fear has been actualised," she shared in a recent Instagram video. "I've been referenced in a South Park episode. I'm so scared."

"I'm going to blind react to it right now," she said.

And as you'd expect, it's pretty scathing.

The clip, which featured fictional character Sharon Marsh walking in the park with Sheila Broflovski, discussed weight loss drugs on the market — including a 'new', more accessible and affordable option.

"Now there's a whole new obesity drug for those of us who can't afford Ozempic and Mounjaro," said Marsh.

"I control my cravings to be thinner, with Lizzo."

Listen: We unpack the pop star's very public reaction on Mamamia Out Loud. Post continues below.

For the uninitiated, Ozempic — which is intended for type 2 diabetes — has exploded in popularity due to its side effects for weight loss, with Hollywood embracing it as a miracle weight-loss drug.

The clip goes on to parody a commercial for the new "once-weekly diet suppressor" dubbed 'Lizzo', claiming that it has "lowered standards and expectations" about weight.

The 'ad' goes on to say "70 per cent of patients on Lizzo no longer care about how much they weigh," claiming the drug allows users to "eat everything" and "keep physical activity to a minimum".

The episode also slams the Good As Hell rapper, continuing, "Stop listening to Lizzo if you experience suicidal thoughts. Serious side effects include pancreatitis, hypothermia and s**tting out your ears."

In the Instagram 'reaction' clip, Lizzo is shown with her eyes wide and her hand covering her mouth in shock. 

"That's crazy," she told her followers. "I just feel like, damn, I'm really that b***h."

Speaking to South Park creators Trey Parker and Matt Stone, she continued, "I really showed the world how to love yourself and not give a f**k to a point where these men in Colorado know who the f**k I am and put it on their cartoon that's been around for 25 years.

"I'm really that b***h and I'll show y'all how to not give a f**k and I'm going to keep on showing you how to not give a f**k."

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A post shared by Lizzo (@lizzobeeating)

An advocate for body positivity, the tide turned on the 36-year-old after a string of allegations in 2023 — including sexual harassment and discrimination, with several of her backup dancers claiming they were 'weight-shamed' by Lizzo.

The singer notably posted an 'I quit' posted after the allegations, before recently re-appearing back on the music scene, bringing about mixed reactions from fans and followers. 

"When I say I quit, I mean I quit giving any negative energy attention," Lizzo shared in a video, addressing backlash. "What I'm not gonna quit is the joy of my life, which is making music, which is connecting to people.

"If I can just give one person the inspiration or motivation to stand up for themselves and say they quit letting negative people win, negative comments win then I’ve done even more than I could have hoped for," she said. 

"I’m going to keep moving forward, I'm gonna keep being me."

Of course, Lizzo isn't the only celeb to be targeted by South Park (and definitely won't be the last — the main series has been renewed until 2027). From Tom Cruise and Ben Affleck to Michael Jackson and even New Zealand singer Lorde, approximately no one is safe from show's creators. Not even the royal family. 

In 2023, the show famously spoofed Prince Harry and Meghan Markle, portraying a fictional Prince and Princess of Canada.

Despite not specifically naming the royal duo, the show went viral for its numerous (and very obvious) references to the Sussexes.

The cartoon famously showed the fictional royals expressing discontent over their lack of privacy, before the couple embarked on a "worldwide privacy tour", for the release of the fictional Prince's new memoir. Sound familiar?

What do you think of the recent South park episode? Share your thoughts in the comment section below. 

Feature image: Instagram/ @lizzobeeating.