Chelsea Handler weighs in on the Brangelina split calling Angelina Jolie a "f*cking lunatic".

Jennifer Aniston has kept quiet since news that her ex-husband Brad Pitt and Angelina Jolie were getting divorced was announced. But her friend Chelsea Handler definitely has an opinion to share.

The comedian shared a preview clip on Twitter from Thursday’s episode of Chelsea on Netflix addressing the famous couples split.

“Brad and Angelina always said they wouldn’t get married until everyone could get married,” says Handler. “And I always said I wouldn’t get married until they got divorced, so I’m officially accepting proposals. I’m ready.”

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The talk show host goes on to address the rumours and tabloid stories about what went wrong in Jolie and Pitt’s marriage that are currently all anyone can talk about.

“There are rumours that part of the problem was Brad was allegedly drinking and smoking too much weed,” Handler explains. “I wonder why he needed to self medicate. Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages?”

Handler then throws down the gauntlet in earnest, adding, “Oh yeah, because he married a fucking lunatic, that’s why!”

As an afterthought Handler concedes, “But we should all respect their privacy during this very difficult time. So, this will be the last time I speak of this …on TV. You can follow me on Twitter.”

This is just the latest in a long history of Jolie bashing by Handler.

Handler has expressed her…um…distaste for the Oscar winner many many times over the years. During an appearance on Watch What Happens Live in March 2013, she even went as far as declare Jolie “seems like a demon.”

“It has nothing to do with Jennifer,” she continued. “As a woman, I know when you see somebody walking across the room that’s a bad girl. I just don’t like Angelina Jolie. I don’t think she’s a girl’s girl. I like girl’s girls!”

And that’s relatively soft for Handler’s anti-Jolie material.

“She’s a home wrecker, she is,” the comedian said during a stand up show in Newark, New Jersey in 2010. “She can rescue as many babies from as many countries as she wants to,” the comedienne continued of the star, who has adopted three kids from around the world. “I don’t fucking believe you. She gives interviews, ‘I don’t have a lot of female friends.’ Because you’re a fucking cunt.”

Harsh.

Rule of thumb, don’t mess with Chelsea Handler’s friends.