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Amanda Knox could face extradition as the latest legal battle commences.

A seven-year legal battle could come to a head this week as courts deliberate on one of the most hotly debated murder cases of our generation.

Amanda Knox, now 28, was on exchange in the Italian town of Perugia in 2007 when she was accused of killing her housemate, 21-year-old British national, Meredith Kercher.

Knox was convicted of that crime, and then acquitted, and then convicted again. She’s now living in America, but a decision of the highest court in Italy this week might see her extradited back to Italy to serve the rest of her 28 year prison sentence.

Experts are now weighing in on whether the US will give her up to Italian authorities.

Amanda Knox.

“Foxy Knoxy”, as Amanda came to be known, was initially found guilty of participating in the stabbing murder of Kercher, but the sentence was reversed in 2011, allowing her to return home to Seattle.

Last year, the original conviction was upheld, and Knox and her former boyfriend Rafaello Sollecito were again found guilty of the murder.

On Wednesday, the court of cassation in Rome will offer the final verdict.

Amanda has always maintained her innocence.

If the guilty verdict is upheld, Knox will face extradition to Italy, to resume a 28-year jail sentence.

While Ms Kercher’s parents are hoping Knox will be forced to pay the price of her alleged crime, sources from the say the likelihood the United States government will extradite Knox is limited, The Independent reports.

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Related content: Amanda Knox is engaged.

According to The Guardian, if an extradition request is made, it would be investigated by the US State Department and then the Justice Department, and would then have to be approved by a US court, where Knox could appeal the extradition. The final decision rests with the US secretary of state, John Kerry.

Several factors could prevent Knox from being extradited, including if she were to give birth to a child.

Amanda in 2007.

The Knox case hit international headlines after Italian media portrayed the accused as a sex-crazed psychopath, after she and Sollecito — her then boyfriend of several days — were seen canoodling after Kercher’s murder.

As more evidence came to light, the Knox narrative switched to “naive and innocent” — a young girl manipulated by the Italian police in a bungled investigation.

Related content: The Amanda Knox retrial: your questions answered.

She, Sollecito and a man named Rudy Guede were all convicted of the murder. Guede is still serving a 16-year prison sentence.

A film loosely based on Knox’ trial entitled ‘The Face of an Angel‘ is set to be released this Friday.

Should Knox be extradited to Italy? Share your thoughts in the comment section below.